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| Human Engineered Cardiac Tissues (hECTs) ： ウィキペディア英語版 |
Human Engineered Cardiac Tissues (hECTs)
Human engineered cardiac tissues (hECTs) are derived by experimental manipulation of pluripotent stem cells, such as human embryonic stem cells (hESCs) and, more recently, human induced pluripotent stem cells (hiPSCs) to differentiate into human cardiomyocytes. Interest in these bioengineered cardiac tissues has risen due to their potential use in cardiovascular research and clinical therapies. These tissues provide a unique in vitro model to study cardiac physiology with a species-specific advantage over cultured animal cells in experimental studies.〔 hECTs also have therapeutic potential for in vivo regeneration of heart muscle.〔〔 hECTs provide a valuable resource to reproduce the normal development of human heart tissue, understand the development of human cardiovascular disease (CVD), and may lead to engineered tissue-based therapies for CVD patients.〔
== Generation of hECTs ==
hESCs and hiPSCs are the primary cells used to generate hECTs.〔〔〔〔 Human pluripotent stem cells are differentiated into cardiomyocytes (hPSC-CMs) in culture through a milieu containing small-molecule mediators (e.g. cytokines, growth and transcription factors).〔 Transforming hPSC-CMs into hECTs incorporates the use of 3-dimensional (3D) tissue scaffolds to mimic the natural physiological environment of the heart.〔〔〔 This 3D scaffold, along with collagen – a major component of the cardiac extracellular matrix – provides the appropriate conditions to promote cardiomyocyte organization, growth and differentiation.〔〔〔〔〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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